![]() El uso se quintuplicó en 2011 respecto a 2002. Se identificaron 11.766 pacientes con una primera prescripción de trazodona en el periodo de estudio. Se llevó a cabo un análisis descriptivo de las principales indicaciones y la comedicación. Se calcularon las tasas de uso por 10.000 personas-año por grupos de edad (66-75 >75) y sexo. Se obtuvo información a partir de datos de BIFAP sobre la dosis, indicaciones, comorbilidades y medicación concomitante. Se llevó a cabo un análisis longitudinal en pacientes > 65 años con una primera prescripción de trazodona durante el periodo 2002-2011. Este estudio tiene como objetivo caracterizar la utilización de trazodona en ancianos en España. La trazodona se autorizó para el tratamiento de la depresión en los años 70, y se han propuesto otros usos por su mecanismo de acción heterogéneo. Trazodone is not being used at high doses, but interacting medicines were frequent, and it may pose additional risks for elderly patients. Trazodone use is increasing in elderly patients, and a high proportion of use in non-approved indications was observed. The use of trazodone concomitantly with interacting medicines was frequent: anti-hypertensives (53.60%), and CNS depressors (59.32%). The most common therapeutic indications were: depression (21.41%), Alzheimer/dementia (20.36%), sleep disorders (16.22%), and anxiety disorder (8.91%). An increasing trend in the use of trazodone was observed (5-fold increase in 2011 as compared to 2002). ResultsĪ total of 11,766 patients receiving a first prescription of trazodone were included. ![]() Incidence rates of trazodone use per 10,000 person-years were calculated by sex and age. Information on dose, comorbidities and relevant co-medication was gathered from the Spanish Primary Care database BIFAP. MethodsĪ nationwide, longitudinal and descriptive analysis was conducted using data from patients aged >65 years with a first prescription of trazodone during the period 2002–2011. This study aims to determine the use of trazodone in the elderly in Spain. Several additional therapeutic uses have been proposed due to its heterogeneous mechanism. Trazodone was authorized for the treatment of depression in the 1970s.
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